Yannan Shen-吉林大学公共卫生学院

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DIVISIONS&DEPARTMENTS

Yannan Shen

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Yan Nan Shen，PhD，Associate professor & Master advisor，Department of Radiobiology

Educational Qualification:

2000/9-2004/7 B.S. in Animal Science, Yanbian University, Long Jing, China

2004/9-2007/2 M.S. in Biology, Kyung Hee University, Seoul, Republic of Korea

2007/3-2011/2 Ph.D. in Biology, Kyung Hee University, Seoul, Republic of Korea

Working Experience:

2011/3-2014/7 Postdoctoral fellow in Korea Institute of Radiological & Medical Sciences (KIRAMS)

2014/8- present Associate professor & Master advisor，Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, China.

Research Fields: Radiobiology; Cancer Biology

(1) functional studies of DNA damage-responsible molecules in cancer cells.

(2) Development of new methods to predict and improve radiotherapy efficacy.

(3) Pharmaceutical company project to identify anti-cancer drug targets and validate its functions in liver cancer.

Founding sources:

functional studies of DNA damage-responsible molecules in cancer cells (Scientific Research Foundation of Jilin University, 350,000￥)

Publications:

1.Kim SH, Park ER, Joo HY, Shen YN, Hong SH, Kim CH, Singh R, Lee KH, Shin HJ. RRM1 maintains centrosomal integrity via CHK1 and CDK1 signaling during replication stress. Cancer Lett. 2014 Jan 14. pii: S0304-3835(14)00014-7.

2.Shen YN, Shin HJ, Joo HY, Park ER, Kim SH, Hwang SG, Park SJ, Kim CH, Lee KH. Inhibition of HAS2 induction enhances the radiosensitivity of cancer cells via persistent DNA damage. Biochem Biophys Res Commun. 2014 Jan 17;443(3):796-801.

3.Woo SR, Byun JG, Kim YH, Park ER, Joo HY, Yun M, Shin HJ, Kim SH, Shen YN, Park JE, Park GH, Lee KH. SIRT1 suppresses cellular accumulation of β-TrCP E3 ligase via protein degradation. Biochem Biophys Res Commun. 2013 Nov 29;441(4):831-7.

4.Joo HY, Woo SR, Shen YN, Yun MY, Shin HJ, Park ER, Kim SH, Park JE, Ju YJ, Hong SH, Hwang SG, Cho MH, Kim J, Lee KH. SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: Implications for cell survival after irradiation. Biochem Biophys Res Commun. 2012 Aug 10;424(4):681-6.

5.YN Shen, SH. Kim, DH Yoon, HG Lee, HS Kang, KS Seo. Proteome Analysis of Bovine longissimus dorsi Muscle Associated with the Marbling Score. Asian-Aust. J. Anim. Sci. 2012. 25(8):1083-1088.

6.Choi SY, Shen YN, Woo SR, Yun M, Park JE, Ju YJ, Jeong J, Shin HJ, Joo HY, Park ER, Lee JK, Kim SH, Cho MH, Kong IS, Lee KH. Mitomycin C and doxorubicin elicit conflicting signals by causing accumulation of cyclin E prior to p21WAF1/CIP1 elevation in human hepatocellular carcinoma cells. Int J Oncol. 2012 Jan;40(1):277-86. (co-first author)

7.Zhang Q, Lee HG, Han JA, Kim EB, Kang SK, Yin J, Baik M, Shen Y, Kim SH, Seo KS, Choi YJ. Differentially expressed proteins during fat accumulation in bovine skeletal muscle. Meat Sci. 2010 Nov;86(3):814-20.

8.Shen YN, Kim YM, Yun CH, Moon YS, Kim SH. Transcriptional activation of pref-1 by E2F1 in 3T3 L1 cells. BMB Rep. 2009 Oct 31;42(10):691-6.

9.Kim NS, Shen YN, Kim TY, Byun SJ, Jeon IS, Kim SH. Expression of AGR-2 in chicken oviduct during laying period. J Biochem Mol Biol. 2007 Mar 31;40(2):212-7.

KS Seo, YN Shen, AJ Salces, DH Yoon, HG Lee, SH. Kim. Correlation Analysis between the Breeding Value of Carcass Traits in Hanwoo (Korean Brown Cattle), Bos Taurus, L. and Spot Intensity on Two-dimensional Gel Electrophoresis. Asian-Aust. J. Anim. Sci. 2006. 19(10):1404-1408.