研究方向：

肺部炎症、气道重塑、氧化性DNA修饰、表观遗传调控

工作经历：

(1) 2025-2 至今， 吉林大学，公共卫生学院，副教授

(2) 2019-6 至 2024-7, University of Texas   Medical Branch at Galveston，Department of   Microbiology and Immunology, Research Fellow, 导师：Ｉｓｔｖａｎ　Ｂｏｌｄｏｇｈ

(3) 2017-09 至 2019-10, 中南大学基础医学院，博士后，合作导师：秦晓群

(4) 2015-01 至 2015-12, University of Texas   Medical Branch at Galveston, Department of Microbiology and Immunology, Visiting   Scholar, 导师：Ｉｓｔｖａｎ　Ｂｏｌｄｏｇｈ

荣誉称号：

唐敖庆学者青年学者

近5年代表性科研项目：

(1) 国家自然科学基金委员会, 青年科学基金项目（C类）[原青年科学基金项目],   31900424, DNA损伤修复蛋白OGG1对肺部炎症的调控及其表观遗传机制 , 2020-01-01 至 2022-12-31, 24万元, 结题, 主持

(2) 国家自然科学基金委员会, 面上项目, 81970033, DNA氧化—甲基化耦联调控哮喘气道上皮整合素β4 低表达机制研究, 2020-01-01 至 2023-12-31, 55万元, 结题, 参与

(3) National Institute of Health, Allergic and Infectious   Diseases, RO1, AI062885, Role of the DNA glycosylase 1 in oxidative   stress-induced innate inflammation, 2019-01 至   2024-08, 218.55

万元, 结题, 参与

(4) National Institute of Health, Neurological Disorders and   Stroke, RO1, NS073976, DNA double strand break repair deficiency and   neurodegeneration, 2019-01 至 2022-04, 203.98万元, 结

题, 参与

近5年代表性学术论文：

(1) Lang Pan; Wenjing   Hao; Yaoyao Xue; Ke Wang; Xu Zheng; Jixian Luo; Xueqing Ba; Yang Xiang;   Xiaoqun Qin; Jesper Bergwik; Lloyd Tanner; Arne Egesten; Allan R Brasier;   Istvan Boldogh; 8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1   (OGG1) is central to fibrogenic gene activation upon lung injury, Nucleic   Acids Research, 2023, 51(3): 1087-1102

(2) Pan, Lang; Wang,   Ke; Hao, Wenjing; Xue, Yaoyao; Zheng, Xu; Basu, Ritwika S.; Hazra, Tapas K.;   Islam, Azharul; Hosakote, Yashoda; Tian, Bing; Gagnon, Matthieu G.; Ba,   Xueqing; Boldogh,

Istvan ; 8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine   in nucleoprotein-associated RNA of respiratory syncytial virus, PLOS   PATHOGENS, 2024, 20(10)

(3) Lang Pan; Yaoyao   Xue; Ke Wang; Xu Zheng; Azharul Islam; Nisha Tapryal; Anirban Chakraborty;   Attila Bacsi; Xueqing Ba; Tapas K. Hazra; Istvan Boldogh ; Nei-like DNA   glycosylase 2 selectively antagonizes interferon-β expression upon   respiratory syncytial virus infection, Journal of Biological Chemistry, 2023,   299(8): 105028

(4) Lang Pan; Istvan   Boldogh ; The potential for OGG1 inhibition to be a therapeutic strategy for   pulmonary diseases, Expert Opinion on Therapeutic Targets, 2024, 28(3):   117-130

(5) Lang Pan; Spiros   Vlahopoulos; Lloyd Tanner; Jesper Bergwik; Attila Bacsi; Zsolt Radak; Arne   Egesten; Xueqing Ba; Allan R. Brasier; Istvan Boldogh ; Substrate-specific   binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal   adaptations to chronic airway injury, Frontiers in Immunology, 2023, 14