副教授

李金华

基本情况

姓名:

李金华

性别:

职称:

副教授

所在部门:

预防医学系——卫生毒理学教研室

最后学历:

研究生

最高学位:

博士

电话:

0431-85619133

Email

jinhua1@jlu.edu.cn


详细情况

所在学科专业:

卫生毒理学

研究方向:

环境毒理学 新药的毒理学安全性评价

讲授课程:

卫生毒理学、分子毒理学、靶器官毒理学、毒理学实验技术、毒理学研究进展、毒理学安全性评价

教育经历:

2003/09 – 2008/06,吉林大学公共卫生学院,本科生(预防医学)
2008/09 – 2010/06,吉林大学公共卫生学院,硕士(环境卫生与劳动卫生
2012/05 – 2017/06,加拿大阿尔伯塔大学,博士(分析与环境毒理)

工作经历:

2017/07 – 至今,吉林大学,公共卫生学院,副教授

科研项目:

1. Identification of new water disinfection byproducts of health importance加拿大NSERC Strategic项目,2015-201845万加元,参与。
2. Research in Analytical/Environmental Chemistry and Toxicology,加拿大NSERC Create项目,2014-2019,15万加元,参与。

3. Novel tools for characterization of new drinking water disinfection byproducts and health effects加拿大NSERC Strategic项目,2011-2015,54万加元,参与。

4. 新型稀土杂多化合物抗乙型肝炎病毒的候选药物研究,国家十一五重大项,2009-2010,241万元,参与。

5. 新型铌取代的杂多化合物抗乙肝病毒活性研究,吉林大学研究生创新研究课题,2010-20111.2万元,主持。

6. 国家自然科学基金面上项目,乳腺癌干细胞辐射抗性的功能蛋白组学研究,2010-201228万元,参与。
7. 国家自然科学基金面上项目,磁性纳米粒子偶联的携带TRAILSmac双基因的条件复制型腺病毒联合放疗、热疗治疗肝癌的实验研究,2009-201135万元,参与。

学术论文:

1. Jinhua LiMadlen BauerBirget MoeElaine M. LeslieXing-Fang LiMultidrug resistance protein 4 (MRP4/ABCC4) protects cells from the toxic effects of halobenzoquinones. Chem. Res. Toxicol., 2017, 30(10):1815-1822.

2. Hanyong Peng, Bin Hu, Qingqing Liu, Jinhua Li, Xing-Fang Li, Hongquan Zhang, and X. Chris Le. Methylated phenylarsenical metabolites discovered in chicken liver. Angew. Chem. Int. Ed., 2017, 56, 6773.

3. Katherine Z. Fu, Jinhua Li, Sai Vemula, Birget Moe, and Xing-Fang Li. Effects of halobenzoquinone and haloacetic acid water disinfection byproducts on human neural stem cells. J. Environ. Sci., 2017, 58, 239-249. (co-first author)

4. Jinhua Li, Birget Moe, Sai Vemula, Wei Wang, and Xing-Fang Li. Emerging disinfection by-products, halobenzoquinones: effects of isomeric structure and halogen substitution on cytotoxicity, formation of reactive oxygen species, and genotoxicity. Environ. Sci. Technol., 2016, 50 (13), 6744–6752.

5. Xiaowen Yan, Jinhua Li, Qingqing Liu, Hanyong Peng, Aleksandra Popowich, Zhixin Wang, Xing-Fang Li, and X. Chris Le. p-Azidophenylarsenoxide: An Arsenical "Bait" for the In Situ Capture and Identification of Cellular Arsenic-Binding Proteins. Angew. Chem. Int. Ed., 2016, 55(45), 14051-14056.

6. Birget Moe, Chungang Yuan, Jinhua Li, Haiying Du, Stephan Gabos, X. Chris Le, and Xing-Fang Li. Real-Time Cell-Electronic Sensing of Coal Fly Ash Particulate Matter for Toxicity-Based Air Quality Monitoring. Chem. Res. Toxicol., 2016, 29 (6), 972–980. (American Chemistry Society (ACS) Editors' Choice)

7. Wei Wang, Birget Moe, Jinhua Li, Yichao Qian, Qi Zheng, Xing-fang Li. Analytical characterization, occurrence, transformation, and removal of the emerging disinfection byproducts halobenzoquinones in water. Trends Anal. Chem., 2016, 85: 97-110.

8. Jinhua Li, Katherine Fu, Sai Vemula, Chris X. Le, and Xing-Fang Li. Studying developmental neurotoxic effects of bisphenol A (BPA) using embryonic stem cells. J. Environ. Sci., 2015, 36, 173-177.

9. Jinhua Li, Wei Wang, Birget Moe, Hailin Wang, and Xing-Fang Li. Chemical and toxicological characterization of halobenzoquinones, an emerging class of disinfection byproducts. Chem. Res. Toxicol., 2015, 28(3): 306-318. (Editorial Advisory Board Members’ Favorite CRT Articles)

10. Jinhua Li, Wei Wang, Hongquan Zhang, X. Chris Le, and Xing-Fang Li. Glutathione mediated detoxification of halobenzoquinone drinking water disinfection byproducts in T24 cells. Toxicol. Sci., 2014, 141(2): 335-343.

11. Wei Wang, Yichao Qian, Jinhua Li, Birget Moe, Rongfu Huang, Hongquan Zhang, Steve E. Hrudey, and Xing-Fang Li. Analytical and toxicity characterization of halo-hydroxyl-benzoquinones as stable haloquinone disinfection byproducts in treated water. Anal. Chem., 2014, 86, 4982-4988.

12. Haiying Du, Jinhua Li, Birget Moe, Claire F. McGuigan and Xing-Fang Li. A real-time cell-electronic sensing method for comparative analysis of toxicity of water contaminants. Anal. Methods, 2014, 6, 2053-2058. (co-first author)

13. Juan Wang, Xiaofeng Qu, Yanfei Qi, Jinhua Li, Xiuling Song, Li Li, Dehui Yin, Kun Xu, and Juan Li. Pharmacokinetics of Anti-HBV Polyoxometalate in Rats. PLoS One. 2014; 9(6): e98292.

14. Haiying Du, Jinhua Li, Birget Moe, Claire F. McGuigan, Shengwen Shen, and Xing-Fang Li. Cytotoxicity and oxidative damage induced by halobenzoquinones to T24 bladder cancer cells. Environ. Sci. Technol., 2013, 47(6):2823-30. (co-first author)

15. Jiahui Wu, Hongfang Wang, Zhicheng Wang, Kai Xu, Yali Qi, Jinhua Li, Shouliang Gong Yang Liu, and Ya Liu. Conditionally replicating adenovirus combined with gene-targeted radiotherapy induces apoptosis via TRAIL death receptors in MDA-MB-231 cells. Molecular Medicine Reports, 2013, 8, 299-305.

16. 王宏芳, 刘扬, 李金华, 吴嘉慧, 李艳博, 王志成, 刘威武, 龚守良. 双重靶向条件复制型腺病毒的包装及抗肿瘤作用. 西安交通大学学报(医学版), 2013, 34(3): 308-312.

17. Yan-fei Qi, Hong Zhang, Juan Wang, Yanfang Jiang, Jinhua Li, Ye Yuan, Shiyao Zhang, Kun Xu, Yangguang Li, Juan Li*, Junqi Niu, Enbo Wang. In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate. Antiviral Research, 2012, 93(1):118-25.

18. 原野, 李金华, 王娟, 张士尧, 鞠文, 齐燕飞, 李娟, 徐坤. 新型多酸化合物NCW-6的毒理学安全性评价. 吉林大学学报(医学版), 2012, 38(1): 28-32.

19. 李金华, 刘扬, 王宏芳, 王志成, 吴嘉慧, 龚守良, 李娟. hTERT启动子调控的TRAIL基因表达载体的构建及其对肝癌细胞增殖的抑制作用. 吉林大学学报(医学版), 2010, 36(5): 825-831.

20. 王宏芳, 李金华, 刘扬, 李艳博, 王志成, 刘威武, 龚守良. 单重靶向条件复制型腺病毒穿梭载体 pshuttle-E1A-E1Bp-E1B55K的构建及鉴定. 吉林大学学报(医学版), 2010, 36(5): 821-824.

21. 王宏芳, 李雪静, 浦昀, 李金华, 徐坤, 宋秀玲, 李娟. 松茸多糖对辐射损伤小鼠免疫功能的保护作用. 西安交通大学学报(医学版), 2010, 31(3): 388-390.

22. 徐坤, 李静, 李金华, 侯雷, 杨松涛, 王宏芳, 浦昀, 吴新宇, 李娟, 夏咸柱. 金刚烷胺修饰物对禽流感病毒感染小鼠免疫功能的影响. 吉林大学学报(医学版), 2009, 35(6): 1011-1104.

著作教材:

1. 刘林林,龚守良等, 主编. 恶性肿瘤生物治疗学. 1.北京: 人民军医出版社, 2013.(校级规划教材,编者)(ISBN:978-7-5091-7151-6)

2. 龚守良, 主编. 肿瘤基因放射治疗学基础. 1. 北京: 人民军医出版社, 2013.(专著,编者)(ISBN: 978-7-5091-6698-7)

获奖情况:

1. Andrew Stewart Memorial Graduate Prize, University of Alberta, April 2016.

2. Outstanding Poster Presentation in DRIvE Day, Edmonton, AB, Canada, April 17-18, 2015.

3. 2nd Prize of DynaLIFEDX Graduate Research Prize, Department of Laboratory Medicine and Pathology, April 2015.

4. Best Graduate Student Oral Presentation in the Chemicals of Emerging Concern section of the 97th Canadian Chemistry Conference and Exhibition, Vancouver, BC, June 1-5, 2014.

5. Judges Choice Poster Award in Streams of Thought (An evening of interdisciplinary water knowledge), Edmonton, AB, March 19, 2014.

6. Best Poster Award in the 10th International Symposium on Persistent Toxic Substances, Edmonton, AB, August 13–17, 2013.

7. 2012–2016 Scholarship from the China Scholarship Council, University of Alberta

8. 李金华 (8/8),多酸化合物抗病毒的作用研究,吉林省自然科学学术成果,二等奖, 吉林省科学技术协会,2016

9. 李金华 (5/9),多酸化合物抗流感病毒、乙型肝炎病毒的作用研究,吉林省公共卫生科学技术奖,一等奖,吉林省预防医学会,2014

10. 李金华 (7/7),新型稀土杂多化合物抗病毒候选药物,吉林省自然科学学术成果奖,一等奖,吉林省科学技术协会,2013

社会兼职:

中华预防医学会卫生毒理分会青年委员

中国毒理学会会员

加拿大化学学会会员

美国毒理学会会员



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