教授

周丽婷

基本情况

姓名:

周丽婷

   

              

性别:

职称:

教授

所在部门:

劳动卫生与环境卫生

最后学历:

研究生

最高学位:

博士

电话:

85619453

Email

zhoult@jlu.edu.cn

 

详细情况

所在学科专业:

劳动卫生与环境卫生学

研究方向:

环境有害因素生物效应与机制

讲授课程:

《环境卫生学》、《卫生学》、《预防医学》、《现代环境卫生学》等

教育经历:

2011/92014/6,   吉林大学, 卫生毒理学, 博士
2009/9
2011/6, 吉林大学, 劳动卫生与环境卫生学, 硕士
2004/9
2009/6, 吉林大学, 预防医学, 学士

工作经历:

2025.09至今  吉林大学  公共卫生学院  教授

2025.02至今 新疆医科大学  公共卫生学院  副院长(中组部援疆)

2022.11至今  吉林大学  公共卫生学院  院长助理

2021.01至今  吉林大学  公共卫生学院  唐敖庆青年学者/励新优秀青年教师

2019.09—2025.09  吉林大学  公共卫生学院  副教授

2015.06—2019.09  吉林大学  公共卫生学院  讲师

2014.09—2015.06  吉林大学  临床第一医学院  博士后

科研项目:

1. 国家自然科学基金,SAA-FPR2通路介导肝内巨噬细胞极化在增塑剂DEHP促进代谢相关脂肪性肝病中的作用机制(82560629),2026.01-2029.12,主持

2. 吉林省科技厅自然科学基金,基于肝脏类器官研究FPR2调控PANoptosis在增塑剂DEHP促进代谢相关脂肪性肝病中的作用机制(20240101286JC),2024.01-2026.12,主持

3. 吉林大学白求恩项目,FPR2的激活在DEHP所致系统性慢性炎症中的调控机制(2022B26),2022.07-2025.06,主持

4.吉林省卫健委公共卫生项目,空气污染对人群健康影响监测与防护,2021.01-2021.12,主持

5. 国家自然科学基金,基于基因芯片研究雌激素受体作用网络在DEHP甲状腺毒性中的作用及其机制(81972996),2020.01-2023.12,第一参与

6. 吉林省教育厅科技发展计划,Notch信号通路在增塑剂DEHP所致脂代谢紊乱中的双调控机制(JJKH20201118KJ),2020.01-2021.12,主持

7. 国家自然科学基金,大气PM2.5通过Notch信号通路调控脂质水平的机制及其在冠心病发生与进展中的作用(81803190),2019.01-2021.12·,主持

8. 横向课题,系统性慢性炎症动物模型构建及治疗靶点开发,2024.12-2027.12,主持

9. 横向课题,肝脏类器官构建,2023.12-2024.12,主持,

10.横向课题,建筑劳务人员健康状况评价分析,2022.09-2024.08,主持

教改论文:

1. 2024.10,“大健康”理念下公共卫生复合型人才培养体系改革与实践—以吉林大学为例,中华疾病控制杂志

2. 2024,以能力培养为导向的多维化环境与健康课程体系构建与实践,医学卓越研究生培养改革的研究与实践

3. 2024,立德树人为根本,育木成材润无声——“学生中心、目标导向”的环境与健康人才培养, 医学卓越研究生教育教学创新实践案例

4. 2024,公共卫生硕士研究生“突发公共卫生事件应急处理”课程改革与实践,医学卓越研究生培养改革的研究与实践

科研论文:

(1) Wu, H.-D.; Yang, L.-W.; Deng, D.-Y.; Jiang, R.-N.; Song, Z.-K.; Zhou, L*.-T. The Effects of Brominated Flame Retardants (BFRs) on pro-Atherosclerosis Mechanisms. Ecotoxicol. Environ. Saf. 2023, 262, 115325. https://doi.org/10.1016/j.ecoenv.2023.115325.

(2) Wang, T.; Zhao, C.; Fang, X.; Zhao, J.; Chao, W.; Bo, Y.; Zhou, L*. Healthful Plant-Based Dietary Patterns Associated with Reduced Adverse Effects of Air Pollution on COPD: Findings from a Large Cohort Study. Nutrients 2025, 17 (6), 1055. https://doi.org/10.3390/nu17061055.

(3) Yang, L.; Zhang, Y.; Qi, W.; Zhao, T.; Zhang, L.; Zhou, L*.; Ye, L. Adverse Effects of PM2.5 on Cardiovascular Diseases. Rev. Environ. Health 2022, 37 (1), 71–80. https://doi.org/10.1515/reveh-2020-0155.

(4) Zhou, L.; Zheng, D.; Song, X.; Zhu, J.; Qi, W.; Ding, S.; Zhang, Y.; Xu, Q.; Han, X.; Zhao, Y.; Zhao, T.; Guo, S.; Shi, Y.; Yang, L.; Ye, L. Alternated mRNA Expression of the Genes in Chromosome 9p21 Is Associated with Coronary Heart Disease and Genetic Variants in Chromosome 9p21. Thromb. Res. 2019, 178, 17–19. https://doi.org/10.1016/j.thromres.2019.03.020.

(5) Zhou, L.; Zhu, Y.; Zhang, T.; Zhang, R.; Liu, Y.; Li, X.; Zhao, W.; Ye, J.; Ju, Y.; Ye, L. ANRIL Regulating the Secretion of Muc5ac Induced by Atmospheric PM2.5 via NF-κB Pathway in Beas-2B Cells. Environ. Toxicol. 2023, 38 (9), 2256–2270. https://doi.org/10.1002/tox.23865.

(6) Ri, H.; Zhu, Y.; Jo, H.; Miao, X.; Ri, U.; Yin, J.; Zhou, L*.; Ye, L. Di-(2-Ethylhexyl) Phthalate and Its Metabolites Research Trend: A Bibliometric Analysis. Environ. Sci. Pollut. Res. Int. 2024, 31 (38), 50142–50165. https://doi.org/10.1007/s11356-024-34533-x.

(7) Xu, Q.; Qi, W.; Zhang, Y.; Wang, Q.; Ding, S.; Han, X.; Zhao, Y.; Song, X.; Zhao, T.; Zhou, L*.; Ye, L. DNA Methylation of JAK3/STAT5/PPARγ Regulated the Changes of Lipid Levels Induced by Di (2-Ethylhexyl) Phthalate and High-Fat Diet in Adolescent Rats. Environ. Sci. Pollut. Res. Int. 2020, 27 (24), 30232–30242. https://doi.org/10.1007/s11356-020-08976-x.

(8) Huo, C.; Song, Z.; Yin, J.; Zhu, Y.; Miao, X.; Qian, H.; Wang, J.; Ye, L.; Zhou, L*. Effect of Acute Cold Exposure on Energy Metabolism and Activity of Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis. Front. Physiol. 2022, 13, 917084. https://doi.org/10.3389/fphys.2022.917084.

(9) Zhang, Y.; Wang, S.; Zhu, J.; Li, C.; Zhang, T.; Liu, H.; Xu, Q.; Ye, X.; Zhou, L*.; Ye, L. Effect of Atmospheric PM2.5 on Expression Levels of NF-κB Genes and Inflammatory Cytokines Regulated by NF-κB in Human Macrophage. Inflammation 2018, 41 (3), 784–794. https://doi.org/10.1007/s10753-018-0732-8.

(10) Liu, Y.; Zhang, B.; Zhang, T.; Wang, H.; Peng, L.; Zhou, L*. Effect of NF-κB Signal Pathway on Mucus Secretion Induced by Atmospheric PM2.5 in Asthmatic Rats. Ecotoxicol. Environ. Saf. 2020, 190, 110094. https://doi.org/10.1016/j.ecoenv.2019.110094.

(11) Qi, W.; Xu, Q.; Xu, Y.; Wang, Z.; Yang, L.; Guo, S.; Shi, Y.; Zhao, T.; Zhou, L*.; Ye, L. Effect of Notch Pathway on Lipid Accumulation Induced by Mono-2-Ethylhexyl Phthalate on 3T3-L1 Cells. Ecotoxicol. Environ. Saf. 2021, 208, 111472. https://doi.org/10.1016/j.ecoenv.2020.111472.

(12) Zhao, T.; Li, X.; Ge, Z.; Shi, J.; Wang, T.; Zhang, J.; Zhang, X.; Jiang, H.; Zhou, L*.; Ye, L. Effects of miR-200b-3p and miR-424-5p Regulating Notch Signaling Pathway on Atherosclerosis Induced by PM2.5in Vitro. Toxicology 2025, 517, 154216. https://doi.org/10.1016/j.tox.2025.154216.

(13) Zhang, T.; Zheng, Y.; Gao, Y.; Zhao, T.; Guo, S.; Yang, L.; Shi, Y.; Zhou, L*.; Ye, L. Exposure to PM2.5 Affects Blood Lipid Levels in Asthmatic Rats through Notch Signaling Pathway. Lipids Health Dis. 2019, 18 (1), 160. https://doi.org/10.1186/s12944-019-1102-8.

(14) Zhou, L.; Zheng, D.; Wang, S.; Zhu, J.; Jia, Y.; Sun, D.; Xu, J.; Wang, Q.; Chen, H.; Xu, F.; Li, B.; Ye, L. Genetic Association of Toll-like Receptor 4 Gene and Coronary Artery Disease in a Chinese Han Population. SpringerPlus 2016, 5 (1), 1533. https://doi.org/10.1186/s40064-016-3177-2.

(15) Zhou, L.; Xie, L.; Zheng, D.; Li, N.; Zhu, J.; Wang, S.; Li, B.; Ye, L. Genetic Variants of CD40 Gene Are Associated with Coronary Artery Disease and Blood Lipid Levels. BioMed Res. Int. 2016, 2016, 1693619. https://doi.org/10.1155/2016/1693619.

(16) Xu, Q.; Ding, S.; Qi, W.; Zhang, X.; Zhang, M.; Xing, J.; Ju, A.; Zhou, L*.; Ye, L. JAK3/STAT5b/PPARγ Pathway Mediates the Association between Di(2-Ethylhexyl) Phthalate Exposure and Lipid Metabolic Disorder in Chinese Adolescent Students. Chem. Res. Toxicol. 2023, 36 (5), 725–733. https://doi.org/10.1021/acs.chemrestox.2c00365.

(17) Zhao, T.; Qi, W.; Yang, P.; Yang, L.; Shi, Y.; Zhou, L*.; Ye, L. Mechanisms of Cardiovascular Toxicity Induced by PM2.5: A Review. Environ. Sci. Pollut. Res. Int. 2021, 28 (46), 65033–65051. https://doi.org/10.1007/s11356-021-16735-9.

(18) Fang, X.; Wang, T.; Lou, S.; Qiao, Y.; Zhang, B.; Zhou, L*. Mechanisms of Di (2-Ethylhexyl) Phthalate-Induced Lipid Metabolism Disorders: A Review. J. Appl. Toxicol. JAT 2025, 45 (12), 2463–2479. https://doi.org/10.1002/jat.4867.

(19) Zhang, Y.; Wang, S.; Zhao, T.; Yang, L.; Guo, S.; Shi, Y.; Zhang, X.; Zhou, L*.; Ye, L. Mono-2-Ethylhexyl Phthalate (MEHP) Promoted Lipid Accumulation via JAK2/STAT5 and Aggravated Oxidative Stress in BRL-3A Cells. Ecotoxicol. Environ. Saf. 2019, 184, 109611. https://doi.org/10.1016/j.ecoenv.2019.109611.

(20) Zhou, L.; Liu, H.; Zhang, R.; Yin, J.; Huo, C.; WangMo, K.; Hua, S.; Ye, L. MUC5B Regulates the Airway Inflammation Induced by Atmospheric PM2.5 in Rats and A549 Cells. Ecotoxicol. Environ. Saf. 2021, 221, 112448. https://doi.org/10.1016/j.ecoenv.2021.112448.

(21) Yin, J.; Ju, Y.; Qian, H.; Wang, J.; Miao, X.; Zhu, Y.; Zhou, L*.; Ye, L. Nanoplastics and Microplastics May Be Damaging Our Livers. Toxics 2022, 10 (10), 586. https://doi.org/10.3390/toxics10100586.

(22) Zhou, L.; Liu, Y.; Chen, X.; Wang, S.; Liu, H.; Zhang, T.; Zhang, Y.; Xu, Q.; Han, X.; Zhao, Y.; Song, X.; Ye, L. Over-Expression of Nuclear Factor-κB Family Genes and Inflammatory Molecules Is Related to Chronic Obstructive Pulmonary Disease. Int. J. Chron. Obstruct. Pulmon. Dis. 2018, 13, 2131–2138. https://doi.org/10.2147/COPD.S164151.

(23) Zhao, T.; Li, X.; Qian, H.; Miao, X.; Zhu, Y.; Wang, J.; Hui, J.; Zhou, L*.; Ye, L. PM2.5 Induces the Abnormal Lipid Metabolism and Leads to Atherosclerosis via Notch Signaling Pathway in Rats. Toxicology 2023, 485, 153415. https://doi.org/10.1016/j.tox.2022.153415.

(24) Zhao, T.; Zhang, Y.; Li, X.; Ge, Z.; Shi, J.; Wang, T.; Zhang, J.; Zhang, X.; Jiang, H.; Zhou, L*.; Ye, L. PM2.5 Induces the Instability of Atherosclerotic Plaques by Activating the Notch Signaling Pathway In Vivo and In Vitro. Environ. Toxicol. 2025, 40 (4), 683–693. https://doi.org/10.1002/tox.24461.

(25) Yang, L.; Song, Z.; Pan, Y.; Zhao, T.; Shi, Y.; Xing, J.; Ju, A.; Zhou, L*.; Ye, L. PM2.5 Promoted Lipid Accumulation in Macrophage via Inhibiting JAK2/STAT3 Signaling Pathways and Aggravating the Inflammatory Reaction. Ecotoxicol. Environ. Saf. 2021, 226, 112872. https://doi.org/10.1016/j.ecoenv.2021.112872.

(26) Huo, C.; Zhu, Y.; Fang, X.; Cui, J.; Ye, H.; Zhao, H.; Ye, L.; Zhou, L*. Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis. Environ. Toxicol. 2024, 39 (11), 5086–5098. https://doi.org/10.1002/tox.24387.

(27) Feng, X.; Zhang, M.; Zhao, T.; Cui, J.; Ye, H.; Zhou, C.; Ye, L.; Zhou, L*. Polystyrene Microplastics Trigger Colonic Inflammation in Rats via the TLR4/NF-κB/COX-2 Pathway and Modulation of Intestinal Microbiota. Toxicology 2025, 513, 154090. https://doi.org/10.1016/j.tox.2025.154090.

(28) Guo, S.; Zhang, B.; Qi, W.; Cao, X.; Xu, Y.; Zhang, X.; Li, X.; Zhou, L*.; Ye, L. Role of Estrogen Receptor Alpha in MEHP-Induced Proliferation and Invasion of SH-SY5Y Cells. Toxicology 2021, 453, 152734. https://doi.org/10.1016/j.tox.2021.152734.

(29) Feng, X.; Zhang, R.; Miao, X.; Li, X.; Cui, J.; Xu, H.; Fang, X.; Zhou, C.; Ye, L.; Zhou, L*. Role of Formyl Peptide Receptor 2 in Steatosis of L02 Cells Exposed to Mono-(2-Ethylhexyl) Phthalate. Environ. Toxicol. 2024, 39 (7), 3967–3979. https://doi.org/10.1002/tox.24256.

(30) Zhang, X.; Qi, W.; Shi, Y.; Li, X.; Yin, J.; Huo, C.; Zhang, R.; Zhao, W.; Ye, J.; Zhou, L*.; Ye, L. Role of miR-145-5p/ CD40 in the Inflammation and Apoptosis of HUVECs Induced by PM2.5. Toxicology 2021, 464, 152993. https://doi.org/10.1016/j.tox.2021.152993.

(31) Liu, Y.; Zhou, L*.; Wu, H.; Wang, Y.; Danzengluobu,; Zhang, B. Role of Notch Signaling Pathway in Muc5ac Secretion Induced by Atmospheric PM2.5 in Rats. Ecotoxicol. Environ. Saf. 2022, 229, 113052. https://doi.org/10.1016/j.ecoenv.2021.113052.

(32) Song, Z.; Wu, H.; Fang, X.; Feng, X.; Zhou, L*. The Cardiovascular Toxicity of Polystyrene Microplastics in Rats: Based on Untargeted Metabolomics Analysis. Front. Pharmacol. 2024, 15, 1336369. https://doi.org/10.3389/fphar.2024.1336369.

(33) Zhou, L.; Chen, H.; Xu, Q.; Han, X.; Zhao, Y.; Song, X.; Zhao, T.; Ye, L. The Effect of Di-2-Ethylhexyl Phthalate on Inflammation and Lipid Metabolic Disorder in Rats. Ecotoxicol. Environ. Saf. 2019, 170, 391–398. https://doi.org/10.1016/j.ecoenv.2018.12.009.

(34) Liu, Y.; Zhou, T.; Sun, L.; Wang, H.; Zhou, L*. The Effect of Notch Signal Pathway on PM2.5-Induced Muc5ac in Beas-2B Cells. Ecotoxicol. Environ. Saf. 2020, 203, 110956. https://doi.org/10.1016/j.ecoenv.2020.110956.

(35) Zhang, R.; Yin, J.; Huo, C.; Li, X.; Ye, J.; Zhao, W.; Zhou, L*.; Ye, L. The Relationship Between Colorectal Polyps and Serum Lipid Levels: A Systematic Review and Meta-Analysis. J. Clin. Gastroenterol. 2022, 56 (8), 654–667. https://doi.org/10.1097/MCG.0000000000001678.

(36) Hui, J.; Yang, L.; Xu, H.; Zhu, Y.; Zhou, L*.; Ye, L. The Relationship between MUC5AC Levels in Lung and Asthma: A Meta-Analysis Based on Animal Experiments. J. Asthma Off. J. Assoc. Care Asthma 2025, 62 (6), 962–974. https://doi.org/10.1080/02770903.2024.2449248.

(37) Wang, X.; Zou, Y.; Zhang, R.; Teng, C.; Ren, X.; Zhang, H.; Zhou, L*. The Relationship between Serum Lipid Levels and Colorectal Serrated Lesions: A Systematic Review and Meta-Analysis. Front. Physiol. 2022, 13, 984586. https://doi.org/10.3389/fphys.2022.984586.

(38) Shi, Y.; Qi, W.; Xu, Q.; Wang, Z.; Cao, X.; Zhou, L*.; Ye, L. The Role of Epigenetics in the Reproductive Toxicity of Environmental Endocrine Disruptors. Environ. Mol. Mutagen. 2021, 62 (1), 78–88. https://doi.org/10.1002/em.22414.

(39) Pan, Y.; Yao, L.; Huang, B.; He, Y.; Xu, C.; Yang, X.; Ma, Y.; Wang, Z.; Wang, X.; Zhu, H.; Wang, M.; Song, L.; Liu, X.; Yu, G.; Ye, L.; Zhou, L*. Time Series Analysis of the Impact of Air Pollutants on Influenza-like Illness in Changchun, China. BMC Public Health 2025, 25 (1), 1456. https://doi.org/10.1186/s12889-025-22110-x.

(40) Yang, L.; Ju, A.; Huang, Y.; Jiang, H.; Ye, J.; Qi, W.; Zhou, L*. Tributyl Phosphate as a Type of Environmental Endocrine Disruptor Associated with Liver Fibrosis: Insights from NHANES and in Vitro Validation. Front. Toxicol. 2025, 7, 1623830. https://doi.org/10.3389/ftox.2025.1623830.

(41) Li, X.; Zhao, T.; Ye, H.; Zhao, H.; Cui, J.; Fang, X.; Zhou, L*.; Ye, L. The Spatio-Temporal Distribution and Risk Assessment of DEHP Exposure Levels in Chinese Adults from 2000 to 2018. Hum. Ecol. Risk Assess. 2024, 30 (9–10), 872–887. https://doi.org/10.1080/10807039.2024.2415956.

(42) Xu, Y.; Fang, X.; Zhao, H.; Ye, H.; Cui, J.; Zhou, L*.; Zhang, Y. Exposure Level and Risk Assessment of Atrazine in Chinese Adults Based on the Systematic Review Data and the Monte Carlo Simulation Method. Hum. Ecol. Risk Assess. 2024, 30 (3–4), 394–408. https://doi.org/10.1080/10807039.2024.2348067.

(43) Han, X.; Gao, Y.; Qi, W.; Ding, S.; Zhang, Y.; Xu, Q.; Zhao, Y.; Song, X.; Zhao, T.; Zhou, L*.; Ye, L. Influencing Factors of Coexistence PreDM and PreHTN in Occupational Population of State Grid Corporation of Chinese. Arch. Environ. Occup. Health 2020, 75 (6), 365–370. https://doi.org/10.1080/19338244.2019.1703623.

(44) Zhang, Y.; Wang, S.; Zhu, J.; Li, C.; Zhang, T.; Liu, H.; Xu, Q.; Ye, X.; Zhou, L*.; Ye, L. Effect of Atmospheric PM2.5 on Expression Levels of NF-κB Genes and Inflammatory Cytokines Regulated by NF-κB in Human Macrophage. Inflammation 2018, 41 (3), 784–794. https://doi.org/10.1007/s10753-018-0732-8.

教学成果奖:

1. 2023.06,“全域、全面、全程、多元”的多维化环境与健康课程体系构建与实践,吉林大学教学成果奖三等奖

2. 2025.10,三维融通、四证合一、开放办学:国家战略引领边疆公共卫生人才培养模式创新实践,新疆自治区教学成果奖二等奖

科研获奖:

1.吉林省人民政府,增塑剂DEHP对糖脂代谢和雌性生殖的毒作用机制,自然科学奖三等奖,2023.12

2.吉林省人民政府,中国汉族人群冠心病遗传易感性的研究,自然科学奖三等奖,2024.11

 

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